Solvent and Guest-Driven Supramolecular Organic Frameworks Based on a Calix[4]arene-tetrol: Channels vs Molecular Cavities

Cone-shaped calix[4]arene-tetrol 3 has the ability to form open structures due presence of four OH groups at upper rim, which allows construction H-bonded supramolecular organic frameworks (SOFs). In water, SOF-1 is formed, contains hydrophilic channels (mean diameter 8.5 Å) contoured by p-phenolic groups. acetonitrile, SOF-2 smaller hydrophobic 6.6 delimited aromatic walls. The Na+@3 complex, hosts acetonitrile molecules in calixarene cavities, and dibromo-calix[4]arene-diol 5 give rise more compact SOFs not containing channels. H-bond network formed all a pinched cone conformation determinant for porosity based on calix[4]arene-tetrol.